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Human anti-Rh(D) monoclonal antibodies, the antibodies for use for passive immunization, anti-Rh(D) reagents and pharmaceutical preparations which comprise the antibodies, human lymphocyte-derived cell lines which produce the antibodies, and a process for determining Rh type using the antibodies
Human anti-Rh(D) monoclonal antibodies, the antibodies for use for passive immunization, anti-Rh(D) reagents and pharmaceutical preparations which comprise the antibodies, human lymphocyte-derived cell lines which produce the antibodies, and a process for determining Rh type using the antibodies
The present invention provides human monoclonal antibodies having the following essential characteristics: (a) exhibiting activity against Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgG3 proteins; (c) having kappa light chains; (d) being of the allotype G3m(21); (e) exhibiting activity against Du cells by an indirect antiglobulin test; (f) exhibiting activity against DIV, DV and DTar variant antigens; and (g) being inactive against DVI or DB variant antigens, which may be employed for Rh-typing of red blood cells and passive immunization to prevent haemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibody of cell line ECACC 86091606 deposited at the European Collection of Animal Cell Cultures, Porton Down, U.K. on 16th September 1987.
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