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Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists
Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists
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机译:阿片受体激动剂和神经激肽-1受体拮抗剂的双功能镇痛药
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摘要
The present invention provides a novel chimeric compound comprising an agonist opioid receptor binding moiety at its N-terminus and an antagonist neurokinin-1 (NK1) receptor binding moiety at its C-terminus for producing analgesia, a pharmaceutical composition comprising the chimeric compound, a method of making the compound, and a method of treating pain using the novel chimeric compounds.
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