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Card-domain containing polypeptides, encoding nucleic acids, and methods of use
Card-domain containing polypeptides, encoding nucleic acids, and methods of use
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机译:含卡结构域的多肽,编码核酸及其使用方法
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摘要
The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are screening methods for identifying CARD-associated polypeptides (CAPs), and for identifying agents that alter the association of a CARD-containing polypeptide with itself or with a CAP. Further provided are methods of altering a biochemical process modulated by a CARD-containing polypeptide, and methods of diagnosing a pathology characterized by an increased or decreased level of a CARD-containing polypeptide.
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