首页> 外国专利> Method for providing a probe for a probe-microscopic analysis of a test sample in a probe microscope and arrangement with a probe microscope

Method for providing a probe for a probe-microscopic analysis of a test sample in a probe microscope and arrangement with a probe microscope

机译：提供用于在探针显微镜中对测试样品进行探针显微镜分析的探针的方法以及具有探针显微镜的装置

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摘要

The present invention relates to a method for providing a measuring probe (1, 1a, 2) for a probe microscopic examination of a sample in a probe microscope, in particular a scanning probe microscope, in which the measuring probe (1), which has a probe base (1a) and a probe extension (2) formed thereon, is held on a carrier device and the measuring probe (1) is processed before or after a measurement by detaching a section of the probe extension (2). The invention further relates to an arrangement having a probe microscope for the probe microscopic examination of a sample, in particular a scanning probe microscope.

机译：本发明涉及一种提供测量探针（ 1、1 a， 2 ）的方法，该探针用于显微镜检查样品中的样品。探针显微镜，特别是扫描探针显微镜，其中测量探针（ 1 ）具有探针底座（ 1 a ）并且在其上形成的探针延伸部分（ 2 ）被保持在一个载体设备上，并且在测量之前或之后通过分离一部分的探针来处理测量探针（ 1 ）。探针扩展名（ 2 ）。本发明还涉及一种具有探针显微镜的装置，该探针显微镜用于样品的探针显微镜检查，特别是扫描探针显微镜。 展开▼

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公开/公告号US7971266B2

专利类型

公开/公告日2011-06-28

原文格式PDF

申请/专利权人 TORSTEN JÄHNKE;TORSTEN MÜLLER;DETLEF KNEBEL;KATHRYN POOLE;
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申请/专利号US20090320114

发明设计人 TORSTEN JÄHNKE;TORSTEN MÜLLER;DETLEF KNEBEL;KATHRYN POOLE;
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申请日2009-01-16

分类号G01N13/16;G01N13/10;G01Q60/24;G01Q60/38;

国家 US

入库时间 2022-08-21 18:08:50

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1. 扫描探针显微镜的测量装置和利用扫描探针显微镜对测量样品进行扫描探针显微测试的方法 [P] . 中国专利： CN112824907A . 2021-05-21

2. 扫描探针显微镜的测量装置和利用扫描探针显微镜对测量样品进行扫描探针显微测试的方法 [P] . 中国专利： CN112098679A . 2020-12-18

3. Method for providing a probe for a probe-microscopic analysis of a test sample in a probe microscope and arrangement with a probe microscope [P] . 美国专利： US2009300807A1 . 2009-12-03

机译：提供用于在探针显微镜中对测试样品进行探针显微镜分析的探针的方法以及具有探针显微镜的装置

4. Measuring device for a scanning probe microscope, scanning probe microscope and method for scanning probe microscopic determination of one or more test samples with a scanning probe microscope [P] . 德国专利： DE102018130349A1 . 2019-06-06

机译：扫描探针显微镜的测量装置，扫描探针显微镜以及利用扫描探针显微镜对一种或多种试样进行扫描探针显微镜测定的方法

5. Measuring Device for a Scanning Probe Microscope, Scanning Probe Microscope and Method for Scanning Probe Microscopic Determination of One or More Test Samples with a Scanning Probe Microscope [P] . 美国专利： US2019170789A1 . 2019-06-06

机译：扫描探针显微镜的测量装置，扫描探针显微镜以及利用扫描探针显微镜对一种或多种试样进行扫描探针显微镜测定的方法

1. Influence of atomic force microscope (AFM) probe shape on adhesion force measured in humidity environment [J] . 阳丽, 涂育松, 谭惠丽应用数学和力学（英文版） . 2014,第005期

2. PROBE-HOLE FIELD EMISSION MICROSCOPE SYSTEM CONTROLLED BY COMPUTER [J] . 巩运明, 曾海山, 张恩虬电子科学学刊：英文版 . 1992,第001期

3. The Methodology of Probe Design with Better Resolution and Less Resistive Donut Probe to Achieve the Best Performance [J] . Mohammad Ismail Talukder, Pepe Siy, Gregory Auner, 仿生工程学报（英文版） . 2009,第003期

4. Heat-transfer Mechanism of Sample-probe in Variable-temperature Scanning Probe Microscope and Influence of Temperature on Tunneling Current [J] . WANG Jing, LI Hong-qi, LIU Mei-hua, Diffusion and Defect Data. Solid State Data, Part B. Solid State Phenomena . 2007,第1期

5. Note: A scanning electron microscope sample holder for bidirectional characterization of atomic force microscope probe tips [J] . Eisenstein Alon, Goh M. Cynthia Review of Scientific Instruments . 2012,第3期

6. Optical method for distance and displacement measurements of the probe-sample separation in a scanning near-field optical microscope [J] . L. Santamaria, C. E. Garcia-Ortiz, H. R. Siller, AIP Advances . 2016,第4期

7. IMPROVED PROBE-SAMPLE SIGNAL BASED MODELING OF SCANNING PROBE MICROSCOPES [C] . Brian Maxwell, Marvin K. Okorafor, Garrett M. Clayton JSME Motion and Vibration Conference;ASME Annual Dynamic Systems and Control Division Conference . 2013

8. Analysis of non-contact and contact probe-to-sample thermal exchange for quantitative measurements of thin film and nanostructure thermal conductivity by the scanning hot probe method. [D] . Wilson, Adam A. 2017

9. Probe versus microscope: a comparison of different methods for image-to-patient registration [O] . Martina Perwög, Zoltan Bardosi, Georgi Diakov, -1

10. Heat-transfer Mechanism of Sample-probe in Variable-temperature Scanning Probe Microscope and Influence of Temperature on Tunneling Current [O] . Wang Jing, Li Hong-qi, Liu Mei-hua, 2015

1. A Cosmic Microscope to Probe the Universe from Present to Cosmic Dawn:Dual-element Low-frequency Space VLBI Observatory [J] . AN Tao ,JAISWAL Sumit ,MOHAN Prashanth . 空间科学学报 . 2019,第002期

2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期

3. 扫描探针显微镜与扫描电子显微镜联合原位纳米力学测试功能开发及应用 [C] . 张跃飞 ,吉元 ,韩晓东 . 第三届全国纳米材料与结构、检测与表征研讨会 . 2012

4. 原子力显微镜中探针与样品的塑性接触对形貌测量的影响 [A] . 孙岩 . 2016