首页>
外国专利>
Mutation in the rat adenomatous polyposis coli gene within the human mutation hotspot region
Mutation in the rat adenomatous polyposis coli gene within the human mutation hotspot region
展开▼
机译:人类突变热点区域内大鼠腺瘤性息肉病大肠杆菌基因的突变
展开▼
页面导航
摘要
著录项
相似文献
摘要
A rat with a disrupted Apc (adenomatous polyposis coli) gene is provided. The mutation can include an A to T transversion changing a lysine to a stop codon at codon 1137. Methods of generating the knockout rat are provided. Also provided is the offspring or progeny of that rat. In addition, methods of using these rats are provided, including methods for screening a carcinogen or a promoter of carcinogenesis, and methods for screening preventive and inhibitory agents of carcinogenesis.
展开▼