Compound N - (((1S, 4S, 6S) - 3 - (2 - piridinilcarbonil) 3-azabicyclo hept-3-ene (4,1.0) - 4-yl) methyl) - 2 - heteroarilamina, their use for the preparation of a Medicament for the treatment of a disease that requires a Human Orexin receptor antagonist Pharmaceutical composition containing same and

摘要

(1) was prepared from n - [(1s, 4S, 6S) - 3 - (2-piridinilcobonil) - 3-azabicil [4.1.0] hept-4-ii] met} - 2-heteromorphic amine,wherein: Het is a heteroaryl group selected from the group consisting of pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl, said heteroaryl group being optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: C1-4 alkyl, halogen , C1-4 alkoxy, C1-4 halogenoalkyl, C1-4 halogenoalkoxy and cyano; R1 is C1-4 alkyl, halogen, C1-4 alkoxy, C1-4 halogenoalkyl, C1-4 halogenoalkoxy, cyano, C1-4-SO2 alkyl, C3-8-SO2 cycloalkyl, C3-8-CH2SO2 cycloalkyl, phenyl or a group 5 or 6-membered heterocyclyl containing 1, 2 or 3 atoms selected from N, O or S,whose phenyl or heterocyclyl group is optionally substituted with C1-4 alkyl, halogen, C1-4 alkoxy, C1-4 halogenoalkyl, C1-4 halogenoalkoxy, or cyano, R2 is C1-4 alkyl, halogen, C1-4 alkoxy, C1 halogenalkyl -4, C1-4 halogenoalkoxy, cyano, phenyl or a 5- or 6-membered heterocyclyl group containing 1, 2 or 3 atoms selected from N, O or S, whose phenyl or heterocyclyl group is optionally substituted with C1-4 alkyl, halogen, C1-4 alkoxy, C1-4 halogenoalkyl, C1-4 halogenoalkoxy, or cyano, R3 is C1-4 alkyl, halogen, C1-4 alkoxy, C1-4 halogenoalkyl, C1-4 halogenoalkoxy, or cyano, m is 0 or 1; and n is 0 or 1;Or a pharmaceutically acceptable salt 2. Use this compound to prepare useful drugs for the treatment of diseases or disorders. This drug requires the antagonists of the human oregiline receptor and the pharmaceutical ingredients including this drug.