Composed of N - (1R, 4S, 6R) - 3 - (2 - piridinilcarbonil) - 3-azabicyclo hept-3-ene 4,1.0 - 4-yl methyl} - 2 - heteroarilamina, their use for the preparation of a Medicament useful for the treatment of a disease that requires a Orexin receptor antagonist Pharmaceutical composition containing Human and

摘要

Composed of N - [(1R, 4S, 6R) - 3 - (2 - piridinilcarbonil) - 3-azabicyclo [4.1.0] hept-3-ene - 4-yl] methyl} - 2 - heteroarilamina, formula (1), Het is a heteroaryl Group selected from the group consisting pirazinilo pyridinyl, pirimidinilo, piridazinilo or heteroaryl Group that is optionally substituted with 1, 2 or 3 substituents selected independently You among the group that is c1-4 alkyl, Halo, c1-4 alkoxy, haloalquilo c1-4, haloalcoxi c1-4,And cyano; r1 is c1-4 alkyl, Halo, c1-4 alkoxy, haloalquilo c1-4, haloalcoxi c1-4 alkyl, cyano, C1 - SO2 - 4 - 8 - SO2, cicloalquil C3, C3 cicloalquil - 8 - ch2so2 phenyl or a group of 5 or 6 members heterociclilo containing 1, 2 or 3 Atoms selected from N, o or S, where the phenyl group or heterocicli It is optionally substituted with c1-4 alkyl, Halo, c1-4 alkoxy, haloalquilo c1-4,Haloalcoxi c1-4 alkyl, cyano or; R2 is c1-4 alkoxy, Halo, c1-4, haloalquilo c1-4, haloalcoxi c1-4, cyano, or a phenyl Group of 5 or 6 members heterociclilo containing 1, 2 or 3 Atoms selected from N, o or s, where the phenyl group or heterociclilo is optionally substituted alkyl C 1 - 4, Halo, c1-4 alkoxy, haloalquilo c1-4, haloalcoxi c1-4 or cyano; R3 is c1-4 alkyl, haloC1-4 alkoxy, haloalquilo c1-4, haloalcoxi c1-4 or cyano; M is 0 OR 1; and N is 0 OR 1; or a pharmaceutically acceptable Salt thereof. Use of said Compound for the preparation of a Medicament useful for the treatment of a disease or Disorder that requires Human Orexin receptor antagonist and Pharmaceutical composition containing same.