Tiadiazoles and Oxadiazoles Derivatives, method of preparation, Synthesis Intermediates, Pharmaceutical compositions containing them and Use thereof in the treatment of Metabolic Disorders such as obesity and diabetes, among others.

摘要

Claim 1: Responding to the compound of formula (1) where u represents an oxygen Atom or a nitrogen Atom, knowing that when u represents an oxygen Atom, then R5 is absent; n is 0, 1, 2 or 3; p is equal to 0, 1 or 2; d represents an oxygen Atom,A link or - NH - Group; W represents a carbon Atom or a nitrogen Atom; X represents a choice between an oxygen Atom or a Sulfur Atom, R1, R2, R3 and R4 represent, independently, a hydrogen Atom, an alkyl group or C1 - 6 or,(i) R1 and R2 can form with the carbon Atom to which are attached a cycloalkyl Group C3 - 10 and / or (ii) R3 and R4 can form with the carbon Atom to which are attached a cycloalkyl Group C3 - 10; and represents a hydrogen Atom, an alkyl group C1 - 6 cycloalkyl, C3 - 10, cicloalquil C3 - 10 - oxilo cicloalquil C3, C1 - 6 - 10 - alkyl - oxilo, heterocicloalquilalquil C1 - 6 - oxilo, a Group coor1,Arylalkyl, aryl, heteroaryl, heterocicloalquilo, ariloxilo, heterocicloalquilo - C (o) -, - C (o) CH (OH) aryl - aryl - NH -, eventually being substituted cycloalkyl groups with one or more substituents selected from a Halogen Atom, a hydroxyl Group, an alkyl group C1 - 6 alkoxy The C1 - 6Heterocicloalquilo or ariloxilo Group; R represents a hydrogen or Halogen Atom; Z1 is absent or is a Sulfur Atom, a function - NH -, -, - NHC (or a Group) - S (o) - CH2 -, - Sch2, or a methylene Group Z2 is absent or Ethylene. Represents a methylene Group, A group o = c = CH - (H) Z3 is absent; AtonIC or represents an oxygen or a methylene Group,A = CH o = C (H) - knowing that only represents a group z2 = C (H) - When is present and represents a group Z3 = C (H) and, Conversely, Z2 and Z3 forming a double Bond; knowing that Z2 and Z3, when present, can to be included in a cycloalkyl Group; Z4 is a hidrog Atom Eno,A carbon Atom that is possibly a Z3 - 10 when a cycloalkyl Group C3 is a group Z3 = CH, or Absent, being then a group Z3 = C (H) - which is a double bond with the carbon that is adjacent to Cyclohexyl; R5 represents a hydrogen Atom or an alkyl group. Often substituted with at least one hydroxyl Group, heterocicloalquilalquilo C1 - 6Alquiloxilo Amine or in the form of acid, base, or Salt added to an Acid or a base.