Tienopirimidinas containing heterocicloalquilo inhibiting Mnk1 Kinases and / or Mnk2, Pharmaceutical compositions containing them and Use thereof for the treatment of Metabolic Disorders such as Diabetes and obesity, and hiperproliferativos disorders, among others.

摘要

1: A compound characterized by a general formula (1), wherein X is ch or N, R1 is h, halogeno, CN, CH3 or CF3, and R2 is a selected (2) group in which (3) - SO2 - (c1-3 tar) can be used instead.-Co - (c1-3 tar)-Co - (CH2) N-O - (c1-3 tar),-CO- (CH2) nN (C1-3 alkyl) 2, C1-4 alkyl, - (CH2) n-CF3, - (CH2) n-CHF2, - (CH2) n-OH, - (CH2) nO- (C1-3 alkyl),- (CH2) n-CN, (4) and where it can be substituted on a carbon atom with a group -CH2OH, where n is 1 or 2, and where the group can be substituted on the nitrogen atom with alkyl (3 ) C1-4 linear or branched, - (CH2) n-CF3, - (CH2) n-CHF2, - (CH2) n-OH, - (CH2) nO- (C1-3 alkyl),-(CH2) n-cn, - (CH2) n-co-n (c1-3 tar) 2, - SO2 - (aiquilo c1-3),-Co - (c1-3 tar)-CO2 (C1-4 tar),-CO2 - (CH2) n-cf3 - (CH2) N-O - (c1-3 tar),-CO2 - (CH2) n-co-n (c1-3 tar) 2, (4) n is 1 or 2, R3 is a group of C1-2 tar, R4 is CO2 (c1-3 tar),-CO2- (CH2) nN (C1-3 alkyl) 2, -CONH2, -CO-NHR5, -CO-NH- (CH2) p-R6, -CO-NH- (CH2) m-R7, -CO- N (CH3) - (CH2) m-R7, CO-N (CH3) - (CH2) -cyclohexyl, (5),R5 is - CN - Oh, C1-6 linear tar or tree branch, or (c1-3 tar),1. Cycloquilo C3-6, SO2 - (c1-3 tar);Methyl can be used instead of pyridine formate, or methyl can be used instead of pyridine glycol. In methyl, NH2, - oh u-och3, - R6 es-c (CH3) 2Cl, - C (CH3) 2OH, - chc3-6 cyclopentadiene, oh can be used instead, methylene can be used instead, pindienediol, 1. C1-3 tar or oxo; tetrahydrofuran; tetrahydropyridine; phenyl, one or two kinds of - F, - Ci, - CN, - Oh, c1-3 U-O tar (c1-3 tar) can be used instead;Naftio; pyridine; furan; thiophosphor; oxazolilo; thiazole; pyrazole; morphine, optionally methyl substituted; benzothion; co-phenyl; o-so2-n (c1-3 tar) 2; R7 is f-oh-ocf3-o - (c1-3 tar)-O-phenyl-o (CH2) m-oh-n (c1-3 tar) 2, - nh-phenyl, pyridyl, pyridyl, Azerbaijani atom or aziridini, in which the hydrogen atom in the NH group can be replaced by c1-3 tar, in which p is 1, 2 or 3, M is 2 or 3, or a sea bream, enantiomero, diastereomero or salt thereof.