Derivatives of 6 - (6-o - triazolopiridazina - sulfanyl) benzotiazoles and benzimidazoles, method of preparing the same and intermediaries that Synthesis, medicines containing them and Use thereof in the treatment of cancer, arthritis, allergies, and other diseases.

摘要

1. Industrial property 1: Formula product (1), wherein - --- represents a simple or double bond; Rb represents a hydrogen atom or a fluorination atom; RA stands for a radical o-z-rc, Z stands for a simple link or linear tar or branch radical, consisting of 1 to 6 carbon atoms, which can be optionally replaced by a group of tar or a halogenated atom; RC stands for a cyclic electrolysis, heterocyclic electrolysis, arilo or alternative isomerization electrolysis; X represents s, so or SO2; a represents NH or s; W represents hydrogen atom; optional tar or cyclopentadiene atom is replaced by alcox, isocyclopentadiene or n3r4;Or a radical COR, in which R represents a cyclopentyl radical, or a radical tar, can choose to replace with a radical nr3r4, alcoxi, o-cycloquilo, o-co-r5, hydroxi, fenilo, isopropyl, or isopropyl propyl, which they choose; an optional alcoxi radical replaces nr3r4, alcoxi, Hydrogen or isocyclopentyl; an n-propyl or n-propyl radical or an n-propyl or n-propyl (CH2) radical with an optional phenyl substitute and N representing an integer of 1 to 4; or an nr1r2 radical with R1 and R2 representing a hydrogen atom, A cyclopentyl radical or a radical tar, and R1 and R2 represent a hydrogen atomA cyclopentyl radical or an optional tar, selected by one or more same or different radicals from hydroxyl, propoxy, isomer, isomerization, isomerization, isomerization, isomerization, nr3r4, alternative phenyl; or R1 and R2 form a cyclic radical with the attached nitrogen, with a strength of 3 to 3. The 10 bonds and the optional one or more different heteroatoms selected from O, s, N and NH may be the optional so or SO2 form; this radical, including its optional NH, is replaced; R3 and R4, the same or different, represent a hydrogen atom, a radical tar,1. Cyclopentyl, non cyclopentyl, heteromorphic or phenyl radicals are all replaced by one or more same or different radicals, which are selected from hydroxy, propyl, heteromorphic, isocyclopenyl, NH2, nhalk, n (ALK) 2, optional phenyl substitutes; Or R3 and R4 form a cyclic excimer with the nitrobenzene atom they are connected to, which is composed of 3 to 10 links, optionally composed of one or more different atoms selected from the O, s, N and NH, and may be in the form of so or SO2; and such excimer, including the optional NH contained therein, Alternative replacement;Tar, alcoxi-o-cycloquilo, cycloquilo, isomerization, isomerization, arilo and phenyl, and periodic radicals containing all of the above definitions, which can form R1 and R2, or R3 and R4, are linked to nitrobenzene atoms and can optionally be replaced by one or more radicals selected from the protons. Halogen, hydroxy, oxo, alcoxi, o-co-r5, or5-cooh, coor5, CONH2, conhr5, NH2, nhr5 ',-Nh-co-r5-nhcoor5 and alchemy, isopropyl Agave, cyclopentyl glycol, isopropyl isopropyl isopropyl ester, ch2-isopropyl, phenyl, phenylisopropyl, isopropyl and isopropyl allylidene, among these last radicals, represents an option. Alchemy radicals, allyl radicals, isopropyl radicals, isopropyl radicals, phenyl radicals, isopropyl radicals and isopropyl radicals all have their own choices It is replaced by one or more radicals selected from hydroxyl, oxo, tar and Alcoy radicals, NH2, nhalk and n (ALK) 2 of halogenated atoms and 1-4 carbon atoms; in addition, there are all the radicals defined above, namely cyclopentyl, isocyclopenyl, isobutylene and phenyl,Option 3; R5 and R5 ',The same or different tar or cyclopentyl radicals representing no more than six carbon atoms; ALK radical tar representing no more than four carbon atoms; it is understood that: (1) if RB represents a simple connection, then RC does not represent a cyclopentyl radical; (2) if RB represents a simple connection, then RC does not represent a cyclopentyl radical Hydrogen and Z represent a tar radical, so RC does not represent isomerization cyclopropyl radical, and these formula products (1) exist in various possible isomers, racemization, dwarfism and isomerization forms,And addictive salts (1) containing minerals and organic acids or minerals and organic bases of these formula products.