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Derivatives of 3 - benzofuranilindol - 2 - ona replaced in 3, its preparation and application in therapy

机译:3中取代的3-苯并呋喃啉衍生物-2-ona的衍生物,其制备方法和在治疗中的应用

摘要

Claim 1: Responding to the compound of formula (1): in which R1 represents a hydrogen Atom or an alkyl group C1 - 6, - C (= o) - alkyl of C1 - 6 or - C (= o) - aryl; R2, R3 and R4, identical or different, located in any of The available positions of the phenyl Nucleus, represent in Independently a hydrogen Atom, a Halogen Atom, CN, oAn alkyl group C1 - 6 eventually substituted with a Halogen Atom or Oh; perhaloalquilo C1 C1 - alkoxy - 3, 6 - 3 aminocarbonilo perhaloalcoxi C1, C1 -, 6 - aminocarbonilo alkyl, dialkyl C1 - 6 - aminocarbonilo, aryl or heteroaryl, ariloxi; being eventually replaced the aryl Group, ar Iloxi or heteroaryl with a Halogen Atom, an alkyl group or NS, oh C1 - 6Perhaloalquilo C1 C1 - alkoxy - 3 or 6; provided that at least one of R2, R3 and R4 is different from H and the aryl or heteroaryl Group, ariloxi eventually can be substituted with a Halogen Atom, an alkyl group or NS, oh perhaloalquilo C1 C1 - 6 - 3, 6 - alkoxy or C1 R5 represents a Group; Lquilo alquenilo C2 or C1 - 6 - 6; n represents 1 or 2; in the form of a base or an Acid Addition Salt.
机译:1。对式(1)的化合物的反应:其中R 1代表氢原子或烷基C 1-6,-C 1-6的烷基或C 1-6的芳基。在苯基核的任何可用位置上,R 2,R 3和R 4相同或不同,独立地表示氢原子,卤素原子,CN,o最终被卤素原子或Oh取代的烷基C1-6。 C 1-烷氧基-3,6- 3个氨基羰基全卤代烷基C1,C1,6-氨基羰基烷基,二烷基C1-6-氨基羰基,芳基或杂芳基,芳基;最终被卤素原子,烷基或NS取代的芳基,碘代或杂芳基,C 1-6全卤代C 1 -C 1-3烷氧基;或只要R2,R3和R4中的至少一个与H和芳基或杂芳基不同,则ariloxi最终可以被卤素原子,烷基或NS取代,哦,全卤代芳基C1 C1-6-3,6-烷氧基C1 R5代表基团;或Lquilo alquenilo C2或C1-6-6; n代表1或2;以碱或酸加成盐的形式存在。

著录项

  • 公开/公告号AR075399A1

    专利类型

  • 公开/公告日2011-03-30

    原文格式PDF

  • 申请/专利权人 SANOFI - AVENTIS;

    申请/专利号AR2010P100379

  • 发明设计人 BARONI MARCO;PULEO LETIZIA;

    申请日2010-02-11

  • 分类号C07D407/14;A61K31/496;A61P3/00;

  • 国家 AR

  • 入库时间 2022-08-21 18:07:27

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