Fcrh5 Antibodies (anti receptor translocation associated with immunoglobulin Superfamily and Immunoconjugates) and Methods of use

摘要

This application relates to compositions useful for the treatment of Hematopoietic tumor in mammals and to methods using these compositions for the same.Claim 1: an Antibody anti fcrh5 comprises (a) at least one HVR Sequence selected from the group consisting of: (i) HVR L1 - that includes the sequence kasqdvstava (SEQ ID no: 26), (ii) HVR - L2 sasyryt (which comprises the sequence SEQ ID no: 27) (iii), which comprises the secuenci HVR - L3 To qqhfssprt (SEQ ID no: 28), (iv) HVR - H1 gftfssyavs (which comprises the sequence SEQ ID no: 35),(V) - H2 HVR atissggsltfildsvr (which comprises the sequence SEQ ID no: 36), (VI) HVR - H3 pipdyyaldy (which comprises the sequence SEQ ID no: 37); and (b) at least one variant of HVR, where the variation of HVR includes Modification of at least one residue the sequence described In SEQ ID no: 26, 2 7, 28, 35, 36 and 37.