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Fcrh5 Antibodies (anti fc receptor homolog) and Immunoconjugates and Methods of use
Fcrh5 Antibodies (anti fc receptor homolog) and Immunoconjugates and Methods of use
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机译:Fcrh5抗体(抗fc受体同源物)和免疫缀合物及其使用方法
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摘要
This application relates to compositions useful for the treatment of Hematopoietic tumor in mammals and to methods using these compositions for the same.Claim 1: an Antibody anti fcrh5 comprises (a) at least one HVR Sequence selected from the group consisting of: (i) HVR L1 - that includes the sequence kasqnvgsnva (SEQ ID no: 28), (ii) HVR - L2 sasyrys (which comprises the sequence SEQ ID no: 29) (iii), which comprises the secuenci HVR - L3 To qqyktwt (SEQ ID no: 30), (iv) HVR - H1 gytftnygmn (which comprises the sequence SEQ ID no: 37)(V) - H2 HVR ntytgeptytddfkg (which comprises the sequence SEQ ID no: 38), (VI) HVR - H3 arrsipyyyamdy (which comprises the sequence SEQ ID no: 39); and (b) at least one variant of HVR, where the variation of HVR includes Modification of at least one residue the sequence described In SEQ ID no: 28, 29, 30, 37, 38 or 39.
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机译:本申请涉及可用于治疗哺乳动物中的造血肿瘤的组合物及其使用该组合物的方法。权利要求1:一种抗体抗fcrh5包含(a)至少一种选自以下的HVR序列:(i) HVR L1-包含序列kasqnvgsnva(SEQ ID no:28),(ii)HVR-L2杂物(其包含序列SEQ ID no:29)(iii),其包含安全性HVR-L3至qqyktwt(SEQ ID No:30),(iv)HVR-H1 gytftnygmn(其包含序列SEQ ID no:37)(V)-H2 HVR ntytgeptytddfkg(其包含序列SEQ ID no:38),(VI)HVR-H3 arrsipyyyamdy(其中包含序列SEQ ID no:39); (b)HVR的至少一种变体,其中HVR的变体包括对至少一个残基的修饰,该残基的序列如SEQ ID no:28、29、30、37、38或39所述。
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