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Composition for immunizing mammals against foot-and-mouth disease virus

机译:用于免疫哺乳动物的口蹄疫病毒的组合物

摘要

Claim 1: a composition to Immunize mammals against the foot-and-mouth disease virus, characterized in that it comprises at least one transgenic plant or part of a transgenic plant that expresses empty capsids are virus disease, where the transgenic plant or part.It includes in its genome, a DNA Construct comprising at least a DNA Sequence encoding a precursor polyprotein P1 bound to a DNA Sequence that encodes the autocatalytic 2a protease.Claim 2: the composition according to claim 1, characterized in that it also includes the Construction of a DNA fragment of a DNA Sequence encoding a fragment of the 2B Protein bound to a DNA Sequence encoding the protease 3C attached to a fragment of the DNA Sequence encoding a Protein fragment 3D.Claim 3: the composition according to claim 3, wherein the vaccine is selected from the set comprised of Parenteral and non parenteral Vaccines, edible. Claim 1: the composition according to claim 7, wherein the transgenic plant is a Plant alfalfa.Claim 1: the composition according to claim 1, characterized in that it comprises at least an adjuvant and / or pharmaceutically acceptable excipient.
机译:权利要求1:用于免疫哺乳动物以预防口蹄疫病毒的组合物,其特征在于其包含至少一种表达空衣壳的转基因植物或部分表达空衣壳的病毒病,其中所述转基因植物或部分。 2.根据权利要求1所述的组合物,其特征在于,所述DNA构建体在其基因组中包括DNA构建体,所述DNA构建体至少包含编码与编码自催化2a蛋白酶的DNA序列结合的前体多蛋白P1的DNA序列。 3.根据权利要求3所述的组合物,其中,所述疫苗的DNA片段的DNA片段编码与编码蛋白酶3C的DNA序列结合的DNA片段,所述DNA片段编码与蛋白酶3C结合的DNA序列。选自可食用的肠胃外和非肠胃外疫苗。权利要求1:根据权利要求7的组合物,其中所述转基因植物是苜蓿植物。1,根据权利要求1的组合物,其特征在于它至少包含佐剂和/或药学上可接受的赋形剂。

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