(3r, 4s) -4- (phenyl-4-hydroxy-protected) -1- (4-fluorophenyl) -3- 3- (4-fluorophenyl) -3-oxoprophyl azetidine-2-one processes for purification

摘要

PROCESSES FOR THE PURIFICATION OF (3R, 4S) -4- (PHENYL-4-HYDROXY- PROTECTED) -1- (4-FLUOROFENYL) -3- [3- (4-FLUOROFENYL) -3- OXOPROPIL] AZETIDINE-2- ONA - Processes are provided for purifying (3R, 4S) -4- (phenyl-4-hydroxy-protected) -1- (4-fluorophenyl) -3- [3- (4-fluorophenyl) -3-oxopropyl] azetidine -2- one with formula II, where X and Y are hydrogen or a substituted or unsubstituted C1-8 alkyl; n is an integer between 0 and 3, and P is a hydroxyl protecting group. The compound of formula II can be converted to an azetidinone compound, which is useful, for example, to reduce cholesterol in mammals.