Crystal structure of (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3- (3-(4-fluorophenyl)-3-oxopropyl)azetidin-2-one, C_(31)H _(25)F_2NO_3

摘要

(Equation presentation) (Table presentation) Source of material The title compound was obtained from nucleophilic substitution reaction of 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4- fluorophenyl)-4-oxoazetidin-3-yl) propanoyl chloride and (4- fluorophenyl)magnesium bromide as described in literature and recrystallized from ethanol solution at room temperature to give crystals suitable for single-crystal X-ray diffraction. Experimental details H atoms were positioned geometrically with C-H = 0.93, 0.97 and 0.98?for aromatic, methylene and methyl, respectively, and constrained to ride on their parent atoms, with Uiso(H) = 1.2 (or 1.5 for methyl groups) times Ueq(C). Discussion (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4- fluorophenyl)-3-oxopropyl)azetidin-2-one is an important intermediate of the synthetic protocol of Ezetimibe [1]. Until now, there are a few examples of Ezetimibe derivatives which have been synthesized and characterized [2-4]. (Table presentation).