compound, pharmaceutical composition, methods for treating a kinase-mediated disorder in a mammal and for treating a proliferation-related disorder in a mammal, and, use of the compound

摘要

COMPOUND, PHARMACEUTICAL COMPOSITION, METHODS TO TREAT A KINASE-MEDIATED DISORDER IN A MAMMER AND TO TREAT A PROLIFERATION-RELATED DISORDER IN A MAMMER AND USE OF THE COMPOUND. The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating protein B kinase mediated diseases (PKB) where the variables have the definitions given herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in the treatment of disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.