compound, methods for treating cancer, for inducing apoptosis and / or necrosis in a trp-p8 expressing cell, pharmaceutical composition, methods for treating a disease or condition, for modulating the trp-p8 receptor function, use of a compound, and method for identifying a trp-8 agonist

摘要

COMPOUND, METHODS FOR TREATING CANCER, FOR INDUCING APOPTOSIS AND / OR NECROSIS IN A CELL EXPRESSING TRP-P8, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING A DISEASE OR RECEPTOR, TRP-P8 FUNCTION , METHOD FOR IDENTIFYING A TRP-P8 AGONIST Trp-p8 small molecule modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising Trp-p8 small molecule agonists, as well as methods for identifying and characterizing, are provided. new small molecule modulators Trp-e methods for decreasing viability and / or inhibiting cell growth expressing Trp-p8, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and / or necrosis, and methods related to the treatment of diseases, including cancers such as lung, breast, colon and / or prostate cancers, as well as other diseases, such as benign prostatic hyperpiasis, which are associated with with the expression of Trp-p8.