Process for obtenu00c7u00e7o complexes with derivatives of cyclodextrins inclusu00e7o of benznidazole

摘要

Process for obtenu00c7u00e7o complexes of inclusu00e7o of benznidazole with derivatives of cyclodextrins.The present invention patent is objective in the process of obtaining complex inclusion of benznidazole (BNZ) (n - benzyl - 2 - (2 - nitroimidazol - 1 - (II) acetamide) and 225 - cyclodextrin (- CD 225) and / or their derivatives (hydroxypropyl 225 - CD., sufobutil 225 CD and 225 CD metilada randomized), Cyclodextrin and cyclodextrin.The solubility of this drug leading to improvement in relation to the drug without complexation and its application in drug formulation of immediate release and / or prolonged the basis of drug for the treatment of Chagas disease.To increase the speed of dissolution of benznidazole by means of its complexation with cyclodextrins in aqueous solution and / or alcoholic in the molar ratio of 1: 1 and / or 1: 2 allows the obtaining of pharmaceutical solids and / or liquid for oral administration, with solubility and / Or dissolution profile modified in relation to the product formulated the basis of the drug not complexed.Giving the medicine greater therapeutic efficacy and lower toxicity.