Nucleoside aryl phosphoramidates and their use as antiviral agents for the treatment of hepatitis C virus

摘要

1.A compound of formula I: wherein: ar includes two or more Aromatic Rings FUSED and are selected from the group consisting of aryl and heteroaryl (C9 - 30) (C6) any such rings are optionally substituted; t is selected from the group consisting of hydrogen (- H), Fluorine (f) (N3), azido, amino (- NH2), hydroxyl (- Oh), alkyl (c1-3) (c1-3)Alkoxyl (C1 - mercapto - (3) - SH) and Alquiltio (c1-3) (C1 - 3S); V is selected from the group consisting of - ot ', Hydrogen (- H), Fluorine (F -) and chlorine (CL), where t is selected from the Group It consists of hydrogen (- H), Methyl (- CH3) (C1 - 16), alkyl (alkyl carbonyl (C1 - 16) - C (= o) - (C2), alquenil Carbonyl (- 18) alquenil (C2 - 18) - C (= o) - (C1), alkoxy carbonyl (- 10) alkyl (C1 - 10) - or - C (= o) -)Cicloalquil (C3 carbonyl (6) cicloalquil (C3 - 6) - C (= o) -), cicloalquiloxy (C3 carbonyl (6) cicloalquil (C3 - 6) - or - C (= o) -); t is selected from the group consisting of hydrogen (- H), Methyl alkyl ((CH3), C1 (16) carbonyl alkyl (C1 - 16) - C (= o) - (C2), alquenil carbonyl (18) alquenil (C2 - 18) - C (= o) -), alkyl XI (C1 - (10) carbonyl alkyl (C1 - 10) - or - C (= o) -), cicloalquil (C3 carbonyl (6) cicloalquil (C3 - 6) - C (= o) -)Cicloalquiloxy (C3 carbonyl (6) cicloalquil (C3 - 6) - or - C (= o) -); n is 0 OR 1.Where is when n = 1, X is o, and when n is 0, there is a double Bond between the 3 and the 4 position and Position x is selected from the group consisting of H, o, F, CL, BR, I, alkyl (C1 - 6) and nr5r6, where each in R5 and R6 is independently selected from H and alkyl (C1 - 6); Z is sele Ccionado group consisting of H, o, F, CL, BR, I, alkyl (C1 - 6) and nr5r6,Where each of R5 and R6 is independently selected from H and alkyl (C1 - 6); and is selected from the group consisting of H, o, F, CL, BR, I, alkyl (6 alquinilo (C1, C2) - 8) and nr5r6, where each) R6 is independently selected from H and alkyl (C1 - 6); Q is Selection The ado group consisting of o, s and cr7r8,...