PROCEDURE FOR SYNTHESIZING DICLORHYDRATE SALT OF ((1S) -1 - (((2S) DICHLORHYDRATE SALT OF ((1S) -1 - (((2S) -2- (5- (4 '- (2 - ((2S) -1 - ((2S) -2 - ((METOXICARBONIL) AMINO) -3-METHYLBUTANOIL) -2-PIRROLIDINYL) -1H-IMIDAZOL-5-IL) -4-BIFENYLIL) -1H-IMIDAZOL-2-IL) - 1-PIRROLIDINIL

摘要

1. This description generally relates to the synthesis of ((1s) - 1 - ((2S) - 2 - (5 - (4) - (2 - ((2S) - 1 - ((2S) - 1 - ((2S) - 2 - ((methylbonil) amino) - 3-methylbutane - (2-pirrolidinil) - 1 h-imidazol-5-il) - 4-bifenill -- 1 h-imidazol-2-il) - 1-pirr(olidinil) carbonil) - 2-methylpropylformate methyl ester. This disclosure also generally relates to intermediaries who are useful in this process. 1. Procedure for preparation of formula compound (7) or acceptable salts on its medicineWithin the EC, this is 0.1 or 2; s is 0, 1, 2, 3 or 4; u and V are selected from 0, 1, 2 or 3 respectively; X is selected from O, s, s (or).If n is 0, X is selected from CH2, CH5 and C (R5) 2; R1 and R2 are selected separately without considering Alcoy, hydrocarbon and halide; if s is 2, CH2, CH2, CH5 and C (R5) 2, each R5 is selected in the ring without considering alcox, hydrocarbon and arilo, Among them, tar can selectively form a concentration ring composed of 3-6 members with adjacent carbon atoms, and 3-6 members can optionally be replaced by one or two tar groups;The condition is that the two heterocycles replacing the imidazole ring are the same, including (a) reacting a formula compound (3), wherein u, V, R1 and R2 are as described in the formula (7);And...