Synthesis of Substituted Aziridine from (1S,2S)-2-Amino-1- (4-Nitrophenyl)- 1,3-Propanediol

摘要

S, 3R)-2-acetooxymethanyl-3-(P-nitrophenyl)-N-tosylaz iridine 5 was synthesized from (1S, 2S)-2-amino-1- (4-nitrophenyl)-1, 3-propaned iol 1 in four steps with a 24.8% overall yield. This reaction is ste reospecific and occ urs an expectable configuration inversion at α-carbon atom of benzyl group. Th e structure of substituted aziridine was determined on FT-IR, NMR, MS and so on .