METHOD OF OBTAINING (1S,2S)-1-(4-HYDROXYPHENYL)-2(4-PHENYLPIPERIDIN-1-YL)-1-PROPANOL METHANESULPHONATE TRIHYDRATE, METHOD OF OBTAINING NOVEL (1S,2S)-1-(4-HYDROXYPHENYL)-2(-4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-D-(-)-TARTRATE AND NOVEL (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXYPHENYL)-2(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOL D-(-)-TARTRATE AS SUCH

摘要

The present invention is directed to a process for the preparation of the mesylate trihydrate of the (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-pro panol compound having the formula (I): CHEM The present invention is also further comprises a process for enantiomeric resolution and isolation of the (D)-(-)-tartrate salt of the compound of the formula (I).