Antagonists of the NMDA receptor for neuroprotection

摘要

Provide compounds, pharmaceutical ingredients, and treatment or prevention methods related to NMDA receptor activity, including neuralgia, cerebrovascular accidents, traumatic brain injury, epilepsy, 1. Compounds or salts, esters, propha or pharmaceutically acceptable derivatives of general formula I: Formula 1: k-ar1 is a single or double ring arilo or heterosexual substitute or non substitute; W is a link, asphalt or acylamine; X is a link, nr1u and each R1 and R2 is a separate h, rental,Alquenilo or aralquilo or R1 and R2 combine to form a ring of 5-8 members; r3r6 is selected from specific substitutes or carbides; and it is a link, O, s, so, so, CH2, NH, n (TAR),it is life.Z is oh, nr6r7, nr8so2 (TAR)N8c (o) n6r7, n8c (o) O (asphalt),Nr8-dihydrotiazol or nr8-dihydroimidazol, or Z, can merge with AR to form a selected heterocycle.