Recombinant attenuated Alphavirus Replication incompetent in mosquitoes and Uses of these

摘要

This Invention describes a recombinant attenuated Alphavirus that is unable to replicate in mosquito cells and transmitted by mosquito vectors. This could include, but is not attenuated Alphavirus imitates the Western equine encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus and Chikungunya Virus.The present Invention also describes the method of Generation of alphaviruses such as immunogenic compositions and their use.