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Selective, local activation of members of the TNF ligand family of systemically inactive non-antibody TNF ligand fusion proteins
Selective, local activation of members of the TNF ligand family of systemically inactive non-antibody TNF ligand fusion proteins
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机译:全身性非抗体非抗体TNF配体融合蛋白TNF配体家族成员的选择性局部激活
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摘要
New polypeptide (I) comprises a segment (1) that contains a binding domain (BD) for a cell-surface molecule; a peptide linker (2) and a segment (3) that contains a fragment of a member (I) of the tumor necrosis factor (TNF) ligand family that, alone, is inactive or has limited activity. BD is not derived from an immunoglobulin and (3) becomes fully active only after binding of (1) to a cell-surface molecule. Independent claims are also included for the following: (1) nucleic acid construct (NAC) that contains a sequence (II) encoding (I); (2) vector that contains NAC; (3) host cell containing NAC and/or the vector of (2); and (4) isolating (I).
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