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PHARMACEUTICAL COMPOSITIONS AND ORAL PHARMACEUTICAL DOSAGE FORM (VARIANTS), EXHIBITING ACTIVITY RELATIVE TO A HIV INFECTION, A PATIENT PACK AND A TABLET
PHARMACEUTICAL COMPOSITIONS AND ORAL PHARMACEUTICAL DOSAGE FORM (VARIANTS), EXHIBITING ACTIVITY RELATIVE TO A HIV INFECTION, A PATIENT PACK AND A TABLET
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机译:药物成分和口服药物剂型(变异体),与HIV感染有关的展览活动,患者包装和片剂
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摘要
The present invention relates to a pharmaceutical combination, an oral pharmaceutical dosage form, a tablet and a patient pack based on therapeutic combinations of [2-(6-amino-purin-9 yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir disoproxil fumarate, Viread ® and (2R, 5S, cis)-4-amino-5-fluoro-l-(2 hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (emtricitabine, Emtriva™, (-)-cis FTC) and their physiologically functional derivatives. The combinations may be useful in the treatment of HIV infections, including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors. The present invention is also relates to a process of preparing said combinations of tenofovir disoproxil fumarate and emtricitabine and a pharmaceutical formulation based thereon.
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