USE OF AN ANTIBODY THAT BLOCKS AN INHIBITORY RECEPTOR OR STIMULATES AN ACTIVATING RECEPTOR OF AN NK CELL FOR THE PREPARATION OF MEDICAMENTS, FOR USE IN COMBINATION WITH A THERAPEUTIC ANTIBODY, IN THE TREATMENT OF A DISEASE, PHARMACEUTICAL COMPOSITIONS COMPRISING SAID ANTIBODIES AND METHODS TO IDENTIFY SAID ANTIBODIES

摘要

The present invention relates, generally, to methods and compositions for increasing the efficiency of therapeutic antibodies. Their efficiency is enhanced through the increase of the ADCC mechanism. More particularly, the invention relates to the use of a therapeutic antibody in combination with compounds that block an inhibitory receptor or stimulate an activating receptor of an NK cell in order to enhance the efficiency of the treatment with therapeutic antibodies in human subjects.