OLIGONUCLEOTIDES COUPLED WITH LIPID, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN INHIBITING TELOMERASE AND IN THE MANUFACTURE OF MEDICAMENTS FOR TREATING CANCER

摘要

Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.