STANDARDIZED EXTRACT AND FRACTION FROM HANCORNIA SPECIOSA LEAVES AND PHARMACEUTICAL COMPOSITION THEREOF

摘要

The present invention describes a standardized extract obtained from the leaves of Hancornia speciosa Gomes (EHS), popularly known as "mangaba" in Brazil, as well as a standardized fraction with inhibiting activity on the angiotensin converting enzyme (ACE), and vasodilating, anti-hypertensive and antioxidant properties. The invention further relates to the preparation of pharmaceutical compositions that contain said extract or fractions derived from the extract of Hancornia speciosa Gomes leaves rich in cyclitols and flavonoids, as well as the use of same for the treatment of cardiovascular diseases such as arterial hypertension, atherosclerosis, stenosis, and non-limiting cardiac or cerebral ischaemia.