STANDARDIZED EXTRACT AND FRACTION FROM HANCORNIA SPECIOSA LEAVES AND PHARMACEUTICAL COMPOSITION THEREOF

摘要

PROBLEM TO BE SOLVED: To provide standardized extracts and fractions from Hancornia speciosa leaves containing kaempferol-3-O-rutinoside, 5-O-caffeoylquinic acid, trans-4-hydroxycinnamic acid and cis-4-hydroxycinnamic acid.SOLUTION: The present invention describes a standardized extract obtained from leaves of Hancornia speciosa Gomes (EHS), popularly known as "mangaba" in Brazil, as well as a standardized fraction with inhibiting activity on an angiotensin converting enzyme (ACE), and vasodilating, anti-hypertensive and antioxidant properties. The invention further relates to preparation of pharmaceutical compositions that contain the extract or fractions derived from the extract of Hancornia speciosa Gomes leaves rich in cyclitols and flavonoids, as well as the use of the same for the treatment of cardiovascular diseases such as arterial hypertension, atherosclerosis, stenosis, and cardiac or cerebral ischemia.