AL+3 /CARBOXYMETHYL LOCUST BEAN NANOPARTICLES BY SURFACTANT-ASSISTED RETICULATION TECHNIQUE

摘要

A novel surfactant-assisted reticulation process was presented for the preparation of water soluble lamivudine-loaded nanoparticles using a newly synthesized carboxymethyl locust bean gum and trivalent Al+3 ions. Depending upon the formulation and processing variables, the drug- loaded nanoparticles could be prepared with reasonable drug entrapment efficiency that will provide a slower drug release profile and a compatible environment.