ETHOSOME COMPOSITIONS OF CURCUMIN FOR TRANSDERMAL DELIVERY

摘要

The invention relates to ethosome compositions for transdermal drug delivery. It specifically relates to transdermal drug delivery compositions in the form of elhosomes of curcumin. More specifically, it relates to transdermal drug delivery ethosome compositions of curcumin in the form of ge] and process lor preparation of elhosomes and their gel forms. The present approach is to overcome the drawbacks of the conventional dosage forms by formulating elhosomes of curcumin using phospholipon 90H, cholesterol ethanol, propylene glycol, distilled water by cold method. The prepared ethosomes were characterized for their entrapment efficiency percentage. Particle Size and size distribution, Zeta Potential, Vesicle Morphology, Degree of Deformability. compatibility study by IR Spectroscopy and DSC, and XRD. The prepared ethosomal gel and free drug gel were characterized for their pH. Spreadability. Consistency, Homogeneity, in vitro drug release behavior, drug deposition study, in vivo studies, and Short term stability study. In vitro studies conclude that ethosomal gel is better than free drug gel for the delivery of curcumin. In vivo studies revealed that the formulation G-5 (ethosomal gel) showed good bioavailability compared to G-6 (free drug gel).