Noncardiotoxic Pharmaceutical Compounds Abstract of the InventionThe present invention relates to novel noncardiotoxic compounds and pharmaceutical compositions useful in the treatment of a variety of disorders including the treatment of depression, allergies, psychoses, cancer and gastrointestinal disorders. In particular, the present invention describes pharmaceutical compositions that mitigate life-threateningarrhythmias such as torsade de pointes. Torsade de pointes is a particular cardiac problem associated with many therapeutic agents and has been implicated as a possible cause of sudden death, particularly in those individuals with a past history of disturbances of cardiac rhythm, myocardial infarction, congenital repolarization abnormalities and cardiac risk factors such as hyperlipidemia and age. This arrhythmiais a variant of paroxysmal ventricular tachycardia associated with a prolonged QTc interval or prominent U waves on the ECG. Torsade de pointes is potentially lethal because it can progress to ventricular fibrillation, life-threatening arrhythmias or precipitate sudden death.(No suitable figure)
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机译:非心脏毒性药物化合物发明摘要本发明涉及新型非心脏毒性化合物和药物用于治疗多种疾病的组合物,包括抑郁症,过敏,精神病,癌症和胃肠道疾病。特别是本发明描述了减轻威胁生命的药物组合物心律失常,如扭转性足尖。 Torsade de Pointes是特别的心脏与许多治疗药物有关的问题,并可能牵连其中突然死亡的原因,尤其是那些有心律失常,心肌梗塞,先天性复极异常和心脏危险因素,例如高脂血症和年龄。这种心律不齐是阵发性室性心动过速与QTc延长相关的变体在心电图上出现间隔或突出的U波。 Torsade de Pointes可能致命因为它可以发展为心室纤颤,危及生命的心律不齐或导致猝死。(没有合适的身材)
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