14,15-DIHYDRO-20,21-DINOREBURNAMENINE-14-OL DERIVATIVES AND THEIR USE

摘要

The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical -AR' wherein A represents a heteroatom and R' represents a group selected from the group comprising linear or branched CSUB1/SUB-CSUB6 /SUBalkyl radicals, CSUB2/SUB-CSUB6 /SUBalkenyls, CSUB2/SUB-CSUB6 /SUBalkynyls, arylalkyls; esters comprising the formula -RSUB1/SUB- CO-O-RSUB2/SUB; amides comprising the formula -RSUB3/SUB-CO-NZY, wherein Y and Z together can form a cycloalkyl radical or a heterocyclic radical, optionally substituted by one or more alkyl radicals; a radical selected from the group comprising alkyl radicals, alkenyls or alkynyls, substituted by at least one amine with formula -NZY; or one of the pharmaceutically-acceptable salts thereof, including the isomers, enantiomers and diastereoisomers thereof and mixtures thereof. The invention also relates to the use of the novel derivatives for the preparation of a pharmaceutical composition which is intended, in particular, for the treatment and/or prevention of depression, sleep-wake cycle disorders and symptomatic frontal disorders in cognitive components among humans.