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OPTIMIZED DNA AND PROTEIN SEQUENCE OF AN ANTIBODY TO IMPROVE THE QUALITY AND EXPLOITATION OF BACTERIALLY EXPRESSED ANTIBODY FUSION PROTEINS
OPTIMIZED DNA AND PROTEIN SEQUENCE OF AN ANTIBODY TO IMPROVE THE QUALITY AND EXPLOITATION OF BACTERIALLY EXPRESSED ANTIBODY FUSION PROTEINS
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机译:抗体的优化DNA和蛋白序列,可提高细菌表达抗体融合蛋白的质量和开发
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摘要
Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired byproduct in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
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