FERTILITY HORMONES WITH VARIABLE LH ACTIVITY (LUTEINISING HORMONE) IN THE FORM OF SINGLE CHAINS

摘要

Glycosylated or nonglycosylated proteins of the formulawherein FSHbeta is a vertebrate follicle stimulating hormone beta subunit or a variant thereof;LHbeta(1-X) refer's to a beta subunit of a vertebrate luteinizing hormone containing positions 1-X where X is an integer of 114-121 or a variant thereof;each "linker" is a hydrophilic, flexible amino acid sequence containing 1-100 amino acid residues;each n is a 0 or 1; andalpha is the alpha subunit of a vertebrate glycoprotein hormone or a variant thereof are useful in protocols to enhance fertility in humans and in animals.