SINGLE-CHAIN FERTILITY HORMONES WITH VARIABLE LH ACTIVITY

摘要

Glycosylated or nonglycosylated proteins of the formula FSHβ-(linker1)n1-LHβ(1-X)-(linker2)n2-α, wherein FSHß is a vertebrate follicle stimulating hormone β subunit or a variant thereof; LHβ(1-X) refers to a β subunit of a vertebrate luteinizing hormone containing positions 1-X where X is an integer of 114-121 or a variant thereof; each 'linker' is a hydrophilic, flexible amino acid sequence containing 1-100 amino acid residue; each n is a 0 or 1; and α is the α subunit of a vertebrate glycoprotein hormone or a variant thereof are useful in protocols to enhance fertility in humans and in animals.