Inhibitor compounds 11beta-hydroxysteroid dehydrogenase type 1.

摘要

Inhibitor compounds 11beta-hydroxysteroid dehydrogenase type 1.; Compounds of formula (I) are derivatives of perhydroquinoline and porhidroisoquinolina and are useful as pharmaceutical active ingredients for the prophylaxis or treatment of diseases caused by associated with the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) disorders such as glaucoma , elevated eye pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, impaired cognition, Alzheimer disease or neurodegeneration.