Inhibitor compounds 11beta-hydroxysteroid dehydrogenase type 1.

摘要

Inhibitor compounds 11beta-hydroxysteroid dehydrogenase type 1.; Compounds of formula (I) are derivatives of perhydroquinoline and porhidroisoquinolina and are useful as pharmaceutical active substances for the prophylaxis or treatment of diseases caused by disorders associated with the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), such as glaucoma, elevated eye pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, impaired cognition, Alzheimer's disease or neurodegeneration.