RNA useful for the manufacture of medicaments for the treatment or prevention of neurodegenerative human diseases, thus obtained interference drugs and their applications.

摘要

RNA interference useful for the manufacture of medicaments for the treatment or prevention of neurodegenerative human diseases, medications thus obtained and applications.; The present invention describes inhibitors of gene expression of the gene encoding the NP1 protein which acts as an inducer of neural apoptosis and neurodegeneration, useful for preparing medicaments or pharmaceutical compositions for the treatment or prevention of human neurological diseases, preferably diseases neurodegenerative. More preferably, the neurodegenerative disease is Alzheimer's. These inhibitors include RNAi acting silencing gene expression NP1 gene.