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Evaluation method of resistance phenotypes of HIV-1 to antiretroviral drugs.

机译：HIV-1对抗逆转录病毒药物耐药表型的评价方法。

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摘要

Evaluation method of resistance phenotypes of HIV-1 to antiretroviral drugs.; In the present invention a method of analysis of phenotypic resistance in HIV-1 clinical samples antiretroviral provided. The method makes use of plasmids which have been created mutations that generate unique sites original sequence, so that permits cloning of fragments progressively larger pol gene and / or the gene encoding the protease of the HIV virus from patients in these plasmids, and thus provides a model to characterize the genes and genomic HIV-1 subregions involved in resistance to antiretroviral drugs.

机译：HIV-1对抗逆转录病毒药物耐药表型的评价方法。在本发明中，提供了一种分析抗逆转录病毒的HIV-1临床样品中表型抗性的方法。该方法利用了已产生突变的质粒，该突变产生了独特的位点原始序列，从而允许克隆逐渐增多的 pol 基因和/或来自HIV病人的编码HIV病毒蛋白酶的基因的片段。这些质粒，从而提供了一个模型来表征与抗逆转录病毒药物抗性有关的基因和基因组HIV-1子区域。 展开▼

著录项

公开/公告号ES2354785B2

专利类型

公开/公告日2011-10-13

原文格式PDF

申请/专利权人 UNIVERSIDADE DE SANTIAGO DE COMPOSTELA;NANOGAP;
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申请/专利号ES20100001193

发明设计人 REGUEIRO GARCIA BENITO JOSE;
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申请日2010-09-30

分类号C12Q1/70;C12N7/00;C12N15/00;C12Q1/68;C12R1/92;

国家 ES

入库时间 2022-08-21 18:02:47

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机译： HIV-1对抗逆转录病毒药物耐药表型的评价方法。

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