Derived tumor associated antigens of the MAGE family, used for the preparation of fusion proteins with helper epitopes ty of compositions for vaccination.

摘要

A fusion protein comprising an encoded gene family MAGE antigen linked to a fusion partner selected from: (i) NS1 protein from influenza or a fragment thereof comprising 81 amino acids N-terminal of NS1; or (ii) LytA from Streptococcus pneumoniae or fragment thereof comprising: (a) the C-terminal portion of LytA; (B) the repeat portion of the LytA molecule found in the C terminal end starting at residue 178; and / or (c) 188-305 amino acid residues of LytA (iii) protein D from Haemophilus influenzae B or a fragment thereof comprising (a) approximately the first 1/3 of protein D; (B) the first 109 amino acids of lipoprotein D; or (c) 100 to 110 amino acid N-terminal protein D