SUBSTITUTED 4-PHENYL-4-1H-IMIDAZOL-2-YL-PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE NON-PEPTIDE DELTA OPIOID AGONISTS

摘要

The present invention relates to novel 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives according to Formula (I), the pharmaceuticallyacceptable acid or base addition salts thereof, the stereochemically isomericforms thereof, the tautomeric forms thereof and the N-oxide forms thereof. Inparticular are claimed compounds according to Formula (I) in which A=B is C=Oor SO2, X is a covalent bond, R1 is alkyloxy, alkyloxyalkyl, Ar or NR9R10,wherein R9 and R10 each independently are hydrogen or Ar; or A=B and R1together form a benzoxazolyl radical ; p is zero, R3 is benzyl optionallysubstituted with hydroxy, alkyl or alkyloxycarbonyl and R4 and R5 each arehydrogen. The invention also relates to processes for the preparation of thecompounds according to the invention and their use in medicine, in particularas selective non-peptide d-opioid agonists for use in the treatment of variouspain conditions.