USE OF THE QUINAZOLINE DERIVATIVE ZD6474 COMBINED WITH PLATINUM COMPOUNDS AND OPTIONALLY IONISING RADIATION IN THE TREATMENT OF DISEASES ASSOCIATED WITH ANGIOGENESIS AND/OR INCREASED VASCULAR PERMEABILITY

摘要

The present invention relates to a method for the production of anantiangiogenic and/or vascular permeability reducing effect in a warm-bloodedanimal such as a human which is optionally being treated with ionisingradiation, particularly a method for the treatment of a cancer, particularly acancer involving a solid tumour, which comprises the administration of ZD6474in combination with a platinum anti-tumour agent; to a pharmaceuticalcomposition comprising ZD6474 and a platinum anti-tumour agent; to acombination product comprising ZD6474 and a platinum anti-tumour agent for usein a method of treatment of a human or animal body by therapy; to a kitcomprising ZD6474 and a platinum anti-tumour agent; to the use of ZD6474 and aplatinum anti-tumour agent in the manufacture of a medicament for use in theproduction of an antiangiogenic and/or vascular permeability reducing effectin a warm-blooded animal such as a human which is optionally being treatedwith ionising radiation.