FLUORO-CARBON EMULSION ENHANCEMENT AGENT FOR HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT AND USE THEREOF

摘要

The present invention discloses a fluoro-carbon emulsionenhancement agent for HIFU treatment, which can increase acousticenergy deposition at the target location during HIFU treatment. Theenhancement agent comprises a discontinuous phase comprising of acore material encapsulated by a membrane-forming material and acontinuous phase comprised of aqueous medium; the discontinuousphase is uniformly dispersed in the continuous phase and the particlesize of the discontinuous phase ranges from 0.1-2µm; the amount ofthe membrane-forming material in the enhancement agent is0.1-100g/L; the core material is comprised of a liquid that undergoesa liquid-gas phase transition at 38-100°C, and the amount of the corematerial in the enhancement agent is 5-200ml/L. The fluoro-carbonemulsion enhancement agent for HIFU treatment of the presentinvention can significantly change the acoustic environment of thetarget location and can increase acoustic energy deposition at thetarget location during HIFU treatment. Eventually, the ability ofclinical HIFU treatment to ablate tumor cells can be significantlyimproved. Accordingly, the present invention discloses use of afluoro-carbon emulsion enhancement agent for HIFU treatmentduring HIFU treatment.