An Intelligent Nanotheranostic Agent for Targeting, Redox-Responsive Ultrasound Imaging, and Imaging-Guided High-Intensity Focused Ultrasound Synergistic TherapyAn Intelligent Nanotheranostic Agent for Targeting, Redox-Responsive Ultrasound Imaging, and Imaging- Guided High-Intensity Focused Ultrasound Synergistic Therapy

摘要

A novel multifunctional nanotheranostic agent with targeting,redox-responsive ultrasound imaging and ultrasound imaging-guided high-intensity focused ultrasound (HIFU) therapy (MSNC-PEG-HAss-PFH,abbreviated as MPHSS-PFH) capabilities is developed. The redox-responsive guest molecule release and ultrasound imaging functions can be both integrated in such a "smart" theranostic agent,which is accomplished by the redox-triggered transition from the crosslinking state to retrocrosslinking state of the grafted polyethylene glycol-disulfide hyaluronic acid molecules on the particle surface when reaching a reducing environment in vitro. More importantly,under the tailored ultrasound imaging guiding,in vivo Hela tumor-bearing nude mice can be thoroughly and spatial-accurately ablated during HIFU therapy,due to the targeted accumulation, responsive ultrasound imaging guidance and the synergistic ablation functions of nanotheranostic agent MPHSS-PFH in the tumors. This novel multifunctional nanoplatform can serve as a promising candidate for further studies on oncology therapy, due to its high stability,responsive and indicative ultrasound imaging of tumors,and enhanced HIFU therapeutic efficiency and spatial accuracy under ultrasound-guidance.