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FLUORO-CARBON EMULSION ENHANCEMENT AGENT FOR HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT AND USE THEREOF
FLUORO-CARBON EMULSION ENHANCEMENT AGENT FOR HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT AND USE THEREOF
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机译:用于高强度聚焦超声治疗的氟碳乳状液增强剂及其用途
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摘要
ABSTRACTThe present invention discloses a fluoro-carbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. Theenhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particlesize of the discontinuous phase ranges from 0.1-2[err]m; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100°C, and the amount of the core material in the enhancement agent is 5-200ml/L. The fluoro-carbonemulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the ability of clinical HIFU treatment to ablate tumor cells can be significantlyimproved. Accordingly, the present invention discloses use of a fluoro-carbon emulsion enhancement agent for HIFU treatment during HIFU treatment.
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