CRYSTALLINE POLYMORPHS OF 5-(2R,3S)-2-(1R)-1-3,5- BIS(TRIFLUOROMETHYL) PHENYL ETHOXY-3-(4-FLUOROPHENYL)-4-MORPHOLINYLMETHYL-1,2- DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE AND PROCESS FOR PREPARATION THEREOF

摘要

Disclosed herein is novel polymorph of 5-[[(2R,3S)-2-[(1R)-1-[3,5- bis(trifluoromethyl) phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2- dihydro-3H-1,2,4- triazol-3-one, commonly known as Aprepitant or pharmaceutically acceptable salts thereof and process for preparation thereof. The present invention further relates to highly pure polymorph, Form II of Aprepitant. The present invention further relates to improved process for preparation of Aprepitant.