METHOD FOR PREPARING POLYMERIZED LIPID CONSTRUCTS, RESULTING POLYMERIZED LIPID CONSTRUCTS, AND USES THEREOF FOR ENCAPSULATING ACTIVE AGENTS

摘要

The present invention relates to a method for preparing polymerized lipid constructs (PLC), characterized in that said method includes the following steps: (a) contacting nanotubes with a lipid solution, said lipids comprising one or two fatty carbon chains, each comprising 6 to 60 carbon atoms and a photopolymerizable dialkyne (─C≡C─C≡C─) group, said fatty chain(s) being bonded to a neutral or charged hydrophilic polar head; (b) adsorbing the lipids around the nanotubes, said adsorption being carried out by strong sonication or agitation; (c) polymerizing the lipids adsorbed around the nanotubes, said polymerization being carried out by ultraviolet irradiation; then, optionally recovering, by purification, the polymerized lipids around the nanotubes; (e) desorbing the polymerized lipids around the nanotubes through sonication or extraction, said extraction being a cold or hot extraction; and (f) recovering the polymerized lipids thus disassembled from the nanotubes, also known as “polymerized lipid constructs” (PLC). The invention also relates to the use of PLCs for the application thereof to the encapsulation of cosmetic or pharmaceutical active agents.